Centella asiatica (Mandukaparni) is a herb which possess neurological, antioxidant and anti-inflammatory activities. Asiaticoside is a constituent of Centella asiatica. Studies have shown that it can inhibit the activity of acetylcholinesterase (AChE). Acetylcholinesterase is an enzyme that catalyses the breakdown of Acetylcholine (Ach), which is a neurotransmitter. When acetylcholine breaks down, neurotransmission is disrupted. So inhibition of acetylcholinesterase increases the level and duration of neurotransmitter action. This in turn improves alertness and concentration.
Curcumin, the principle curcuminoid found in Curcuma longa (Haridra), has been identified for its nueroprotective function. It also enhances the generation of new cells, called as neurogenesis. Curcumin has the ability to modulate various neurotransmitters in brain including acetylcholine. The structure and molecular weight of curcumin allows it to penetrate the blood-brain barrier effectively, especially in the presence of MCT from Coconut. Moreover, it is rich in antioxidants, having anti-inflammatory actions. It is also a natural detoxifier.
Ocimum Sanctum, commonly called as Holy basil (Tulasi), is known for its healing power as a herb. Ursolic acid and Eugenol are the most important bioactive components. Ursolic acid protects against neurotoxicity in brain. It inhibits oxidative stress and exerts anti-inflammatory effects, thereby indicating that it prevents brain cell damage and improves the functioning of brain.
The most potential nootropic effect of Ashwagandha is due to its bioactive component known as Withanolides. The highest concentration of this component is present in its roots. It promotes intellect, memory, cognition, prevents neurodegenerative disorders and also is a mood stabiliser. Studies have shown that it helps in dendrite formation and enhances neurotransmission. Moreover, Ashwagandha is an Adaptogen, that normalizes systemic functions, regulates physical-mental stress, and elevates functioning performance of the body.
Proanthocyanidins found in Vitis Vinifera (Draksha), inhibits inflammation by various mechanisms. They significantly reduce oxidative stress and enhance the synthesis of Glutathione which is an antioxidant. It inhibits DNA fragmentation and modulates apoptosis. Recent studies show that Proanthocyanidins provides complete protection for neurotransmitters, and hence it is a preventive agent against neurotoxicity.
Cocos Nucifera (Narikela) contains Medium Chain Triglycerides, that are easily absorbed by the body. In addition to that, the phenolic compounds and cytokinins found in it inhibits neurodegeneration. It supports cognitive functions and enhances memory. It has the ability to correct stress induced damage as well.
Tribulus Terrestris (Gokshura) contains bioactive compounds which inhibits MonoAmine Oxidase, and increases the level of Dopamine in brain.